Widnes will travel to Nantwich Town in the first round of the 2019-20 Integro League Cup.
The tie will take place at the Weaver Stadium on Tuesday 17 September, kick-off 7:45pm.
It is the second successive season that Widnes have been drawn away to a Northern Premier League Premier Division side in the first round of the competition, with the Whites beaten at Witton Albion last term.
Dave Cooke's Nantwich side were beaten play-off semi-finalists in the Premier Division last season, and currently sit seventh after the opening four games of the season.
Admission details are to be confirmed in due course.